Detective Chief Inspector Andy Partridge, said: "The incident took place outside a venue that was hosting a private party.
"A number of witnesses have already been spoken to, but it is clear many others who were present are yet to be traced, some of whom may have captured the attack on their mobile phones.
"It appears the deceased and the two injured males were working as security staff for the party, they were attacked by a group of males who were outside trying to enter the venue.
"The female was also attacked as she assisted the security staff in closing the front door of the premises.
"This shocking incident happened just hours into a New Year, the area was particularly busy with people out celebrating and making their way home from various parties and organised events."
A Scotland Yard spokesman added: "Detectives have launched a murder investigation following a stabbing in the West End.
"Police were called at 5:36am on Tuesday, 1 January to a property on Park Lane in Westminster to reports of a stabbing.
"Officers and the London Ambulance Service attended.
"A man, believed to be in his early 30s, was found with stab injuries. Despite the efforts of officers and paramedics he was pronounced dead at 6:05am.
"His next of kin are in the process of being informed. A post-mortem examination will be held in due course.
"Two other men - aged 37 and 29 - and a 29-year-old woman were also found with stab injuries.
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